MBT2-10E: Essential Bioinformatics

These days biology handles enormous amount of data generated, among others, in the genome sequencing projects. Thus integration of information technology into biology becomes increasingly important and in consequence, there is a great need for personnel with combined skills in mathematics, computing and biological science. Bioinformatics is a new branch of bioscience which uses computational models and databases to manage DNA and protein sequences for pharmaceutical healthcare and biomanufacturing purposes. The bioinformatics course covers the following areas: [1] accomplishing bioinformatics tasks on UNIX running computers and methods for visualisation of molecular structure (PyMOL), [2] internet resources for molecular biologists, biophysisits and biotechnologists, [3] sequence analysis with applications of EMBOSS package and visual detection of sequence similarities (dotter, dottup, dotmatcher), [4] local and global sequence alignment methods, [5] heuristic algorithms for searching sequence databases (BLAST, FASTA).

Students during the course can collect up to 100 points. 30% of them can be collected during lab exercises, 20% are from seminars, 30% from a practical test, and 20% from a single-choice test. The practical classes end with a grade (pts for active participation in practicals + the result of the practical test). The lectures ends with a grade being determined from points for the single-choice test and seminars. The The following grading policy is used:

  • F (failing, 2.0) 0-49 pts
  • D (passing, 3.0) 50-59 pts
  • C (average, 3.5) 60-69 pts
  • B (good, 4.0) 70-79 pts
  • B+ (very good, 4.5) 80-89 pts
  • A (excellent, 5.0) 90+ pts.

Course delivarables:

A student, who completes the course, knows how to:

  • search sequence and literature databases
  • properly use specialized bioinformatics vocabulary and make clear connections between basic terms and research methods
  • identify and quantitatively compare homologous sequences of proteins and nucleic acids
  • recognize the role of bioinfomatics methods in modern biosciences
  • work both individually and collectively on solving typical bioinformatics problems

A student, who completes the course, can:

  • use programs from EMBOSS, BLAST, and FASTA packages to compare sequences and perform various sequence related analyses
  • query bioinformatics services and interpret obtained results

Lectures (9h), computer labs (27h), and seminars (9h): each meeting / module 4h+ lonh, 45h in total:

  • Monday (9:00-12:00, D111, 2 meetings)
computer labs
  • Monday (9:00-12:00, D111, 6 meetings)
  • Monday (9:00-12:00, D111, 2 meetings)
class schedule (all classes online using the Teams plaform)
  • March 2021: 15.03 Lecture module #1, 22.03 Computer Lab module #1, 29.03 Computer Lab module #2

  • April 2021: 12.04 Lecture module #2, 19.04 Computer Lab module #3, 26.04 Computer Lab module #4

  • May 2021: 10.05 Seminar module #1, 17.05 Seminar module #2, 24.05 Computer Lab module #5, 31.05 Computer Lab - Crash test

  • June 2021: 7.06 the practical test (2h), break, the single choice (+2/-1/0) test (1h)


  • Bioinformatics and molecular evolution, Higgs & Attwood, Wiley-Blackwell, 2004

BioInfoCourses: BioinformaticsInEnglish (last edited 2021-03-13 16:30:01 by KrzysztofMurzyn)