Lipid - protein interactions
Numerous experimental results contradict a commonly held belief that the lipid bilayer matrix of biomembranes is a passive and structureless 'solvent' for the membrane proteins. In fact, it appears that the membrane lipids play active roles in the membrane proteins functioning both by providing an interface with the fluid membrane environment and interacting specifically with integral or peripheral proteins. In this project, a molecular dynamics (MD) simulation method is applied to study these properties in a hydrated bilayer. The method is well suited for this purpose, the time and length resolutions being superior to those provided by experimental methods.